Oxidized Low-Density Lipoprotein Cholesterol and the Ratio in the Diagnosis and Evaluation of Therapeutic Effect In Patients with Coronary Artery Disease
نویسندگان
چکیده
OBJECTIVE The purpose of the present study was to investigate the value of ox-LDL and oxidation ratio of LDL (ox-LDL/TC, ox-LDL/HDL-C and ox-LDL/LDL-C) in diagnosis and prognosis evaluation in CAD patients. Also, we aimed to observe the effect of statins on reducing level of ox-LDL and oxidation ratio of LDL, and explore whether statins still have similar effect on ox-LDL in a short period of therapy (within 2 weeks). METHODS Blood ox-LDL, TC, HDL-C, LDL-C, and TG were measured in cases with acute myocardial infarction (AMI, n=177), unstable angina pectoris (UAP, n=195), stable angina pectoris (SAP, n=228), normal control (n=120), and high risk control (n=140). RESULTS Mean value of ox-LDL and oxidation ratio of LDL was significantly higher in the CAD group than in the two control groups. The AUC of ROC curve of ox-LDL, ox-LDL/TC, ox-LDL/HDL-C, ox-LDL/LDL-C and apoA1/apoB were more than 0.50 (P < 0.001). Multivariate logistic regression analysis showed that age and ox-LDL/LDL-C related with short-term, while ox-LDL/LDL-C and ox-LDL/TC related with long-term prognosis (p < 0.05). Furthermore, after treatment with statins for 2 weeks, TC, LDL-C, ox-LDL, ox-LDL/TC, ox-LDL/HDL-C and ox-LDL/LDL-C decreased by 22%, 28%, 38%, 29%, 23% and 25% respectively. And the reduction of ox-LDL by statins is independent of lowering of LDL-C and TC. CONCLUSIONS Ox-LDL and oxidation ratio of LDL are closely related with AS, and they are better biomarkers for discriminating between patients with coronary artery disease and healthy subjects. In addition, statins can decrease level of ox-LDL significantly, which is independent of lowering of LDL-C and TC.
منابع مشابه
The association between small dense low density lipoprotein,apolipoprotein B, apolipoprotein B/apolipoprotein A1 ratio and coronary artery stenosis
Abstract Background: Recently, small dense low density lipoprotein (sdLDL) has been highlighted as a new risk factor for the coronary artery disease (CAD).Small dense LDLs are believed to be atherogenic since these particles are taken up more easily by arterial wall. They are readily oxidized and have reduced affinity for low density lipoprotein (LDL) receptor and increased affinity...
متن کاملEvaluation of Lipid Profile in Women with Female Pattern Alopecia
Background: The correlation between coronary artery disease and androgenic alopecia has been demonstrated, but the mechanism of this association still remains to be cleared. Objective: To investigate lipid profile, as an indicator of coronary artery disease, in women with female pattern alopecia. Methods: Fifty one women with female pattern alopecia and thirty one healthy women with normal hair...
متن کاملThe Effectiveness of Rehabilitation-Education Program on Risk Factors in Patients with Coronary Artery Disease
Introduction: Cardiac rehabilitation programs refer to interventions aimed at stopping the recurrence of coronary artery disease in patients. The purpose of this study was to determine the effect of rehabilitation-education program on risk factors in patients with coronary artery disease. Methods: In this clinical trial study 70 CAD patients who were admitted to coronary care units of Ali-Ebne ...
متن کاملLow high density lipoprotein cholesterol levels and acute coronary syndrome in young patients admitted at a tertiary care facility
Background: Coronary artery disease (CAD) is a cardiovascular disease which is related to mortality and morbidity among the Indians predominantly in the older age group. But, recently CAD has been found more often in young population. Hence, our study aims to observe the outcomes based on various categories of high density lipoprotein (HDL) cholesterol levels estimated during admission at the h...
متن کاملAssociation of androgenetic alopecia and hyperlipidemia
Background an objective: Several studies have indicated that vertex type androgenetic alopecia have a higher-than-normal risk for coronary heart disease but few studies focused on lipid profiles which are important in the pathogenesis of coronary heart disease. This study was designed to investigate the relation between vertex type androgenetic alopecia (Grade III and higher according to ...
متن کاملEVALUATION OF SERUM CHITINASE-3 LIKE 1 PROTEIN AND C-REACTIVE PROTEIN LEVELS IN TYPE 2 DIABETES MELLITUS WITH CORONARY ARTERY DISEASE COMPARED TO DIABETIC AND HEALTHY CONTROL
Background: Diabetes mellitus, which is associated with elevated blood glucose, lipids and liver enzymes, may results in alterations in the production of inflammatory cytokines, including chitinase-3-like protein 1 (YKL-40) and high-sensitivity C-reactive protein (hs-CRP), which induce and promote complications of diabetes such as atherosclerosis.The aim of this study was to evaluate the serum ...
متن کامل